Method for the targeted treatment of depression

ABSTRACT

A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled responses concerning the degree to which the patient&#39;s mental state is affected by at least one or both of impaired modulation and impaired activation. Next, the patient&#39;s answers will be processed to arrive at scores for the at least one impaired modulation and impaired activation. Depending upon the patient&#39;s scores for demodulation and deactivation, at least one medication which affects the at least one impaired modulation and impaired activation is recommended.

BACKGROUND OF THE INVENTION

[0001] The invention relates to clinical depression, the leading cause of medical disability in the world, and more specifically to a method for determining what antidepressant regimen is best suited for a patient with depression.

[0002] Presently, there are few guidelines for determining the appropriate agents to use in treating depressed patients. Traditional thinking holds that all antidepressants are the same except for side-effects. This assumption is based on the fact that all antidepressants show approximately the same level of effectiveness (50-70%) in studies on undifferentiated depressed populations. However, recent investigations which differentiate between subtypes of depression indicate that matching antidepressants with specific subtypes can improve results. Unfortunately, none of the depression assessment tools currently available identify these subtypes (e.g., DSM-IV-TR, Hamilton, Beck, Montgomery-Asberg, Zung). Thus, many health professionals seeing such patients fail to make the proper diagnosis and, when they attempt to treat may not always use medications optimally.

[0003] There accordingly remains a need for an improved method that permits even inexperienced providers to quickly, easily, inexpensively, and accurately determine which type of depression is present (e.g. whether the depression is primarily characterized by (1) impaired CNS modulation, with typical symptoms of anxiety, irritability, hostility, impulsivity, agitation, hypochondriasis, or suicidality; (2) impaired activation, with common symptoms of fatigue, apathy, anhedonia, hypersomnia, lack of initiative, inability to concentrate, and decreased productivity, or (3) a combination of both types) and to prescribe the treatment regimen that is most likely to lead to clinical improvement.

[0004] A half century ago the discovery that depression was often improved by medications affecting monoamine neurotransmitters led to several optimistic “one disease-one neurotransmitter” theories. The norepinephrine and serotonin hypotheses of depression posited simple synaptic deficiencies of these chemicals as the basis of depression. Advances in neuroscience and more rigorous clinical research ultimately demonstrated problems with these theories, such as delays in clinical improvement until weeks or months after correction of putative synaptic deficiencies and the comparable efficacies in undifferentiated depressed populations. By the end of the 20^(th) century, identification of complex intraneuronal pathways involving multiple signaling systems and neuroadaptive genetic transcription mechanisms seemed to offer more compelling explanatory possibilities. Thus, most practitioners have been encouraged to believe that differences between serotonergic and catecholaminergic antidepressants are of little importance.

[0005] The concept of “targeted treatment” in depression, i.e., the use of a particular class of antidepressant against a particular depressive subtype, had until recently found little scientific support. Over a quarter century ago Klein and his co-workers showed “dirty” antidepressants such as tricyclics and monoamine oxidase inhibitors's (MAOI'S) to be somewhat more beneficial in melancholia and a typical depression, respectively. However, since 1988, with the introduction of “cleaner” agents like fluoxetine (Prozac and others), selective serotonin reuptake inhibitors (SSRI's) have demonstrated higher efficacies than catecholaminergic agents in treating many disorders such as anxiety, panic, phobias, postraumatic stress (PTSD), premenstrual disorder (PMS) and obsessive-compulsive disorder (OCD). On the other hand, catecholaminergic agents such as bupropion (Wellbutrin) and reboxetine have shown greater effectiveness in restoring energy, motivation and libido. Supporting the idea that neurotransmitter mechanisms matter, depletion experiments have shown that the condition of a successfully treated depressed patient will worsen if depleted of the neurotransmitter that his or her antidepressant treatment has targeted, but not if other neurotransmitters are depleted. Similarly, pre-treatment Q-EEG measurements can predict whether depressed patients will respond to a serotonergic as opposed to another type of antidepressant. In severe depressions, dual mechanism regimens (serotonergic and catecholaminergic) are more effective than monotherapies.

[0006] Because of the potential clinical importance of targeting, the inventor has been studying and matching selective serotonergic and catecholaminergic antidepressants to particular subtypes of depression for over a decade. The naturalistic outpatient study on which the invention is based involved 1000 depressed patients. In a random sample of 100 patients who were treated according to the invention's targeting algorithm, 96% were improved (CGI ratings <3) compared with 65% given standard non-targeted treatment (n=55). More recently, 12 patients who received the wrong treatment according to the invention exhibited only 29% as much improvement as 84 people treated according to the invention's recommendations.

[0007] Embodying the knowledge gained in these studies, the invention provides clinicians in diverse settings with a rapid, user-friendly method for selecting antidepressants that are more likely to prove effective.

SUMMARY OF THE INVENTION

[0008] The invention provides a new treatment-oriented method of characterizing the primary depressive subtypes.

[0009] The invention further provides a method of detecting and quantifying those subtypes.

[0010] The invention also provides a non-invasive method for determining which type of antidepressant (serotonergic, catecholaminergic or dual-mechanism) is most likely to improve that subtype of depression.

[0011] The invention yet further provides a method for determining when to modify or discontinue the initial treatment regimen.

[0012] The invention also provides a method for optimizing dosages of antidepressant medications.

[0013] The invention additionally provides a method for warning professionals when the potential for suicidal behavior has been detected.

[0014] The invention uses a bipolar scale to represent the range from depression to euthymia to mania.

[0015] In addition, the invention provides both manual paper and pencil and computerized formats for achieving its objectives.

[0016] Other features and advantages of the invention will be apparent from the following description of the preferred embodiments hereof, and from the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

[0017]FIG. 1 is a Venn diagram, showing the modulatory effects of serotonin and the activating effects of the catecholamines (norepinephrine and dopamine) in normal human functioning.

[0018]FIG. 2 is Venn diagram showing the symptoms of impaired modulation and activation secondary to reduced serotonin, norepinephrine and dopamine neurotransmission in depression.

[0019]FIG. 3 depicts the scoring sheet of the invention in its self-administered “paper and pencil” version.

[0020]FIG. 4 depicts an exemplary screenprint of the invention's scoring screen in a Windows or Macintosh-based operating system.

DETAILED DESCRIPTION OF THE INVENTION

[0021]FIG. 1 is a Venn diagram showing the modulatory effects of serotonin and the activating effects of the catecholamines (norepinephrine and dopamine) in normal human functioning without depression.

[0022]FIG. 2 is Venn diagram showing the symptoms of impaired modulation and activation secondary to reduced serotonin, norepinephrine and dopamine neurotransmission in depression.

[0023] Table 1 shows the serotonergic, noradrenergic and dopaminergic activity of some of the commonly available and more selective antidepressant medications. TABLE 1 GENERIC/ BRAND SEROTONIN NOREPINEPHRINE DOPAMINE BUPROPION/ X X WELLBUTRIN CITALOPRAM/ X CELEXA FLUOXETINE/ X PROZAC FLU- X VOXAMINE/ LUVOX MIRTAZPINE/ X X REMERON PAROXETINE/ X X PAXIL SERTRALINE/ X X ZOLOFT VENLAFAXINE/ X X EFFEXOR

[0024] Table 2 shows the clinical features of the depressive subtypes. TABLE 2 SUBTYPE REACTIVITY ENERGY SLEEP APPETITE DEMODULATED INCREASED SAME OR DECREASED DECREASED INCREASED DEACTIVATED DECREASED DECREASED INCREASED SAME OR INCREASED MIXED VARIABLE VARIABLE VARIABLE VARIABLE

[0025] Table 3 shows the relationship between TTDI scores and depressive subtypes. TABLE 3 SUBTYPE STANDARD NAMES M SCORE A SCORE D SCORE DEMODULATED ANXIOUS ELEVATED NORMAL OR ELEVATED AGITATED LOW HOSTILE HYPOCHONDRIACAL DEACTIVATED PSYCHOMOTOR- NORMAL OR ELEVATED ELEVATED RETARDED LOW BLUNTED APATHETIC MIXED MELANCHOLIC ELEVATED ELEVATED ELEVATED ATYPICAL REFRACTORY

[0026]FIG. 3 depicts an embodiment of the invention in its self-administered “paper and pencil” version.

[0027] The formula for calculating M and A scores from Items 1-17 (I1-I17) of FIG. 3 is as follows:

M=I1+I3+I5+I6+I8+I10−I11−I12+I14+I16  Formula 1

A=−I2−I4−I7−I9+I11+I12−I13−I15+I17  Formula 2

[0028] Table 4 demonstrates an exemplary programming script for calculating the M and A scores on a Palm Pilot handheld computer utilizing a proprietary database management system for the Palm operating system. Alternate programs can be used for other personal digital assistants, handheld computers, laptop computers, and other computerized devices. TABLE 4 M calculation: A calculation: result = $4 + $6 result = result − $5 result = result + $8 result = result − $7 result = result + $9 result = result − $10 result = result + $11 result = result − $12 result = result + $13 result = result + $14 result = result − $14 result = result + $15 result = result − $15 result = result − $16 result = result + $17 result = result − $18 result = result + $19 result = result + $20 answer = result − 15 answer = result + 12

[0029]FIG. 5 depicts an example of the invention's Windows or Macintosh-based scoring screen.

[0030] Embodiment A—Standard 17-Item Form

[0031] Turning now to a further description, in EMBODIMENT A of the invention, a 17-item (plus 2 historical or “H” items) multiple choice test that identifies and quantifies two dimensions which have been found by the inventor to correlate with the need for serotonergic and catecholaminergic antidepressants, respectively. These questions are as follows, and are weighted as follows:

[0032] 1. I've been anxious

[0033] a lot less than usual (−2), somewhat less than usual (−1), the same as usual (0), somewhat more than usual (+1), or a lot more than usual (+2)

[0034] Questions 2-15 have the same possible response possibilities as question 1, and are as follows:

[0035] 2. I've felt energetic . . .

[0036] 3. I've been angry . . .

[0037] 4. I've felt motivated

[0038] 5. My health has worried me . . .

[0039] 6. People have annoyed me . . .

[0040] 7. I've experienced enjoyment . . .

[0041] 8. I've felt agitated . . .

[0042] 9. I've taken initiative . . .

[0043] 10. I've lost control of my emotions . . .

[0044] 11. I've slept . . .

[0045] 12. I've eaten . . .

[0046] 13. I've had good concentration . . .

[0047] 14. I thought about death . . .

[0048] 15. I've felt productive . . .

[0049] Questions 16 and 17 have a different scoring criteria, as follows

[0050] 16. If I were to take medication now, I would want it to help me feel . . . a lot calmer (+4), somewhat calmer (+2), no calmer than usual (0)

[0051] 17. If I were to take medication now, I would want it to help me feel . . . a lot more energetic (+4), somewhat more energetic (+2), no more energetic than usual (0)

[0052] The dimensions are called the M score, measuring the need for central nervous system (CNS) modulation, and the A score, measuring the need for CNS activation. The scores can range as high as +34 or as low as −26 with 0 representing normal. Positive scores tend to be directly proportional to the degree of depressive pathology present and the dosage of medication that may be required. Small negative scores usually reflect better than average functioning, while large negative scores can reflect bipolar pathological states such as mania.

[0053] In a typical application of the invention, a health professional administers the test to a patient in an outpatient or hospital treatment setting. When administered in its non-computerized form (FIG. 3), the test is scored by comparing the patient's paper and pencil responses to a printed scoring key or by inputting the manual responses into computer containing the invention's software program. When administered using a touch-screen monitor, keyboard or PDA powered by that software, the patient's scores and recommended treatment parameters can be provided instaneously to the treating professional.

[0054] The test is divided into ten M items that measure impaired modulation and nine A items that measure reduced activation. As shown in Eormulas 1 and 2, the two items included in both series (11. I've slept . . . 12. I've eaten . . . ) affect scores in opposite directions, i.e., sleeping excessively adds 2 to the A score and subtracts 2 from the M score and eating excessively adds 2 to the A score and subtracts 2 from the M score. When positive, the historical items 18 and 19 may add weight to the treatment recommendations, but are not included in the M or A scores, which reflect current states only.

[0055] When patients first seek treatment these scores typically reflect the overall level of depression. This is quantified as the D score, which equals the total of the positive M and A scores. Negative M and A scores are not permitted to lower the D score because the severity of a depressive subtype is not reduced by lack of symptoms in a non-contributory dimension. For example, a patient whose A score is elevated is no less depressed simply because his or her ability to manifest anger or irritability (components of the M score) is less than usual. The negative M score in such a case may actually be a function of the reduced energy associated with severe DEACTIVATION.

[0056] Scoring Examples:

[0057] (a) If M=12 and A=11, then D=23. This would be an example of the MIXED subtype.

[0058] (b) If M=−3 and A=14; then D=14. This would be an example of the DEACTIVATED subtype.

[0059] (c) If M=15 and A=+1, then D=16. This would be an example of the DEMODULATED subtype.

[0060] While the D score resembles the scores derived on traditional unidimensional depression tests such as the Hamilton Depression Inventory, the M and A subscales are unique. When the M score is greater than 4 the invention classifies the patient as DEMODULATED and recommends treatment with a serotonergic antidepressant. Correspondingly, when the A score is greater than 4 the invention identifies the patient as DEACTIVATED and recommends treatment with a catecholaminergic antidepressant. When both M and A scores are above 4 the invention diagnoses a MIXED state and calls for dual-mechanism antidepressant treatment. No other depression test that the inventor is aware of offers this type of pharmacological guidance.

[0061] To add even more clinical usefulness, there are three levels of severity associated with each state: MILD, MODERATE AND SEVERE. MILD states are defined as those with M or A scores from 5 to 9. MODERATE states are those with M or A scores from 10 to 14. SEVERE states have M or A scores of 15 or more. Recommended treatment dosages increase with level of severity.

[0062] The test is usually repeated two to four weeks after receiving treatment to assess improvement. If the medication is working, the difference between the patient's present condition and his baseline “normal” state will have decreased, resulting in D, M and A scores approaching 0. If that is not the case, as for example when a DEMODULATED patient (elevated M score only) has become secondarily DEACTIVATED by his SEROTONERGIC medication (decreased M score, newly elevated A score), the invention recommends treating this effect of initial treatment with the appropriate agent (e.g., combining the SEROTONERGIC agent with a CATECHOLAMINERGIC antidepressant), typically resulting in improvement or recovery within a few weeks.

[0063] Again, the five possible responses to Items 1 through 15 are weighted either: −2, −1, 0, +1 and +2 (M items) or +2, +1, 0, −1, or −2 (A items). For example, Item 1, an M item, is scored as follows I've been anxious a lot less somewhat less the same somewhat more a lot more than usual than usual as usual than usual than usual −2 −1 0 +1 +2

[0064] Feeling a lot MORE anxious than usual (the DEMODULATED response) raises the M score by 2, whereas feeling a lot LESS anxious than usual (the more MODULATED response) lowers it by 2. Feeling the SAME as usual leaves the score unaffected.

[0065] Item 2, an A item, is scored the opposite way: I've felt energetic a lot less somewhat less the same somewhat more a lot more than usual than usual as usual than usual than usual +2 +1 0 −1 −2

[0066] Feeling a lot MORE energetic than usual (the more ACTIVATED response) LOWERS the A score by 2, while being a lot LESS energetic than usual (the DEACTIVATED response) RAISES it by 2. The invention reverses the choices associated with increased pathology on the two scales in this manner to reduce false positive and negative errors caused by the repetitive selection of the same choice and to provide an immediate indication to the clinician of discrepancies between test-taking behavior and clinical manifestations of deactivation and/or demodulation.

[0067] Items 16 and 17 have only 3 choices, but are weighted more heavily than the other items. Item 16 contributes to the M score as shown: If I were to take medication now, I would want it to help me feel somewhat no calmer a lot calmer calmer than usual +4 +2 0

[0068] Item 17 contributes similarly to the A score: If I were to take medication now, I would want it to help me feel a lot more somewhat no more energetic energetic more energetic than usual +4 +2 0

[0069] Methods for calculating the total M and A scores are shown in Formulas 1 and 2, respectively, for a paper and pencil calculation, and in Table 4, which is a program script for a calculating the M and A scores on a Palm Pilot® handheld computer utilizing a proprietary database management system for the Palm operating system. In Table 4, the “$” symbol designates field values followed by a number equal to the item number +3, e.g., “$4” is the raw score for Item 1. Raw scores, which are a function of the requirements of the software used, are corrected when necessary by adding or subtracting the difference between raw and real scores, which in this example is −15 for the M score and +12 for the A score. (These compensatory calculations are required in this case because the Palm Pilot® database management system restricts the 5 choices per item to the integers 1 through 5 rather than −2 through +2.)

[0070] Other programming platforms used by the invention, e.g., on Windows and Macintosh computers, utilize other scoring algorithms to arrive at identical results. Moreover, because of their larger screens, laptop and desktop computers can offer more detailed graphic and text-based information in connection with the invention's, software, an example of which is shown in FIG. 4.

[0071] For example, when a score of +1 or +2 is obtained for Item 14 (thinking about death “somewhat” or “a lot more than usual”), a warning message appears on the screen to evaluate the patient's suicidal potential with language proportional to the potential danger, and color graphics are used to reinforce these warnings. The invention graphically depicts changes over time in the patient's condition, permitting monitoring and modification of treatment as needed.

[0072] Embodiment B—Short Form

[0073] EMBODIMENT B of the invention utilizes items 11, 16 and 17 plus two more M and two A scale items (“IM^(x)”, “IM^(y)”, “IA^(x)”, “IA^(y)”) to guide treatment. IM^(x),IM^(y),IA^(x) and IA^(y) can be selected by the professional user during the software set up process. The formulas for calculating M and A scores in this version are:

M=2(IM ^(x) +IM ^(y) −I11+I16)  Formula 1

A=2(IA ^(x) +IA ^(y) +I11+I17)  Formula 2

[0074] Multiplying by 2 brings the scores derived in EMBODIMENT B into the same range as those of EMBODIMENT A. While this shorter form may be less comprehensive and accurate than the 17 item version, it can still provide useful guidance in selecting and managing antidepressant treatment. It further offers the professional an opportunity to abbreviate and customize the test to fit his own practice needs.

[0075] Embodiment C—Psychobiological Form

[0076] In its psychobiological form, the invention utilizes data from physiological measures such as the Q-EEG, serum platelet serotonin assay, and the urinary MHPG to derive the M and A scores. While at the present time, these methods are far more expensive and cumbersome than EMBODIMENTS A and B, new developments in neuroscience suggest that more cost-effective methods will soon be available. These approaches will utilize the principle on which the invention is based, i.e., inferring CNS serotonin and catecholamine levels to determine the most effective antidepressant treatment, by measuring various physical concomitants of that neurotransmitter activity. For example, recent work in neurogenetics suggests that it may soon be possible for physicians to determine in seconds whether patients have the diathesis (genetic tendency) for serotonin or catecholamine impairment or both. The invention will provide a method for doctors to combine or substitute such physical data for the clinical data derived using the items in FIG. 3.

[0077] The present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents. In this context, equivalents mean each and every implementation for carrying out the functions recited in the claims, even those not explicitly described herein. 

What is claimed is:
 1. A method for determining the appropriate medication for a patient suffering from depression, comprising: having a patient take a questionnaire wherein the patient answers a plurality of questions with scaled responses concerning the degree to which the patient's mental state is affected by at least one or both of impaired modulation and impaired activation; processing the patient's answers to arrive at scores for the at least one impaired modulation and impaired activation; and depending upon the patient's scores for demodulation and deactivation, determining at least one medication which affects the at least one impaired modulation and impaired activation.
 2. The method of claim 1, wherein the questions concerning the patient's impaired modulation include at least one question about at least one of a patient's level of anxiety, anger or hostility, concern for health or hypochondriasis, irritability or annoyance, impulsivity or agitation, control of emotions, hypersomnia or amount of sleep, amount eaten, suicidality, and feeling about how the medication should make the patient feel about calmness.
 3. The method of claim 1, wherein the questions concerning the patient's impaired activation include at least one question about at least one of a patient's level of fatigue or energy, apathy or motivation, sense of enjoyment, initiative, amount of sleep, amount eaten, ability to concentrate, productivity, and feeling about how the medication should make the patient feel about being energetic.
 4. The method of claim 2, wherein the questions concerning the patient's impaired activation include at least one question about at least one of a patient's level of fatigue or energy, apathy or motivation, sense of enjoyment, initiative, amount of sleep, amount eaten, ability to concentrate, productivity, and feeling about how the medication should make the patient feel about being energetic.
 5. The method of claim 1, wherein high scores for impaired modulation are used to indicate treatment with at least one serotonergic antidepressant medication.
 6. The method of claim 5, wherein the at least one serotonergic antidepressant medication is selected from the group consisting of citalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline.
 7. The method of claim 1, wherein high scores for impaired activation are used to indicate treatment with at least one catecholaminergic antidepressant medication.
 8. The method of claim 7, wherein the at least one catecholaminergic antidepressant medication is selected from the group consisting of bupropion or bupropion SR.
 9. The method of claim 1, wherein high scores for both impaired modulation and impaired activation are used to indicate treatment with at least one serotonergic antidepressant medication and at least one catecholaminergic antidepressant medication or at least one dual mechanism antidepressant medication.
 10. The method of claim 9, wherein the at least one dual mechanism antidepressant medication is selected from the group consisting of venlafaxine and mirtazapine.
 11. The method of claim 1, wherein the questions on the questionnaire include at least some selected from questions directed to the patient's feeling concerning his/her relative level of anxiety, energy, anger, motivation, concern about health, annoyance, experience of enjoyment, agitation, initiative, control over emotions, sleep, eating, concentration, thoughts about death, productivity, wish that medication taken now would affect his/her level of calmness, and wish that medication taken now would affect his/her energy level.
 12. The method of claim 1, wherein the questionnaire is manually taken by the patient by paper and pencil and is scored by hand.
 13. The method of claim 1, wherein the answers to the questions of the questionnaire are processed and scored by a computer, with the computer providing the recommended antidepressant therapy.
 14. The method of claim 13, wherein the computer keeps track of the patient's prior scores to provide a record of the patient's history and to monitor the patient's response to the treatment.
 15. The method of claim 1, wherein the method is further used to recommend dosing for the medications prescribed.
 16. The method of claim 1, wherein the questions concern: (a) the amount of sleep the patient has had compared to usual; (b) if the patient were to take medication, would the patient want the medication to help the patient feel a lot more calm, somewhat more calm, or no more calm than the patient feels at the time of response; (c) if the patient were to take medication, would the patient want the medication to help the patient feel a lot more energetic, somewhat more energetic, or no more energetic than the patient feels at the time of response; (d) at least two questions selected for the group consisting of questions concerning the level of anxiety, anger, concern about health, annoyance, agitation, control over emotions, amount eaten, and thoughts about death experienced by the patient; and (e) at least two questions selected from questions concerning the level of energy, motivation, experience of enjoyment, initiative, good concentration, and feeling of productivity.
 17. The method of claim 2, wherein the questions concerning the patient's impaired modulation are scored at as very high for answers that the patient feels a lot more of the question, high for answers that the patient feels somewhat more of the question, average for the patient feels the same as usual of the question, low for answers that the patient feels somewhat less of the question, and very low for answers that the patient feels a lot less of the question.
 18. The method of claim 17, wherein for the question about the patient's feeling about how the medication should make the patient feel about calmness, a lot calmer is rated as +4, somewhat calmer is rated as +2, and no calmer than usual is rated as 0, and for the other questions, very high scores are equal to a score of +2, high scores are given a score of +1, average scores are given a score of 0, low scores are given a score of −1, and very low scores are equal to a score of −2, and wherein a total score for all answers of 15 and more indicates severe demodulation, a total score for all answers of between 10 to 14 indicates moderate demodulation, a total score for all answers of between 5 to 9 indicates mild demodulation, and a total score of 4 or less indicates no significant demodulation.
 19. The method of claim 3, wherein the questions concerning the patient's impaired activation are scored at as very low for answers that the patient feels a lot more of the question, low for answers that the patient feels somewhat more of the question, average for the patient feels the same as usual of the question, high for answers that the patient feels somewhat less of the question, and very high for answers that the patient feels a lot less of the question.
 20. The method of claim 19, wherein for the question about the patient's feeling about how the medication should make the patient feel about being energetic, a lot more energetic is rated as +4, somewhat more energetic is rated as +2, and no more energetic than usual is rated as 0, and for the other questions, very high scores are equal to a score of +2, high scores are given a score of +1, average scores are given a score of 0, low scores are given a score of −1, and very low scores are equal to a score of −2, and wherein a total score for all answers of 15 and more indicates severe deactivation, a total score for all answers of between 10 to 14 indicates moderate deactivation, a total score for all answers of between 5 to 9 indicates mild deactivation, and a total score of 4 or less indicates no significant deactivation.
 21. The method of claim 4, wherein the questions concerning the patient's impaired modulation and activation are scored at as both very high and very low, respectively for answers that the patient feels a lot more of the question, both high and low, respectively for answers that the patient feels somewhat more of the question, average for answers that the patient feels the same as usual of the question, both low and high, respectively for answers that the patient feels somewhat less of the question, and both very low and very high, respectively for answers that the patient feels a lot less of the question.
 22. The method of claim 21, wherein for the question about the patient's feeling about how the medication should make the patient feel about being calm and energetic, a lot more calm and energetic is rated as +4 for both, somewhat more calm and energetic is rated as +2 for both, and no more calm and energetic than usual is rated as 0 for both, and for the other questions, very high scores are equal to a score of +2, high scores are given a score of +1, average scores are given a score of 0, low scores are given a score of −1, and very low scores are equal to a score of −2, and wherein a total score for all answers of 15 and more indicates severe demodulation or deactivation, a total score for all answers of between 10 to 14 indicates moderate demodulation or deactivation, a total score for all answers of between 5 to 9 indicates mild demodulation or deactivation, and a total score of 4 or less indicates no significant demodulation or deactivation.
 23. The method of claim 22 wherein the method is further used to determine the presence of a bipolar syndrome by determining the level of depression and/or mania and the contributing dimensions of modulation, activation, demodulation and/or deactivation in a patient utilizing a bivalent number scoring criteria, wherein elevated positive demodulation and/or deactivation numbers correlate to the degree of depression the patient is experiencing, and negative deactivation numbers (over-activation) correlate to the degree of mania the patient is experiencing.
 24. The method of claim 23 wherein a total score ranging from −5 to −9 suggests the presence of hypomania and a total score ranging −10 to −26 suggests the presence of mania.
 25. The method of claim 22, wherein a total score for either modulation and/or activation in the range of −1 to −5 indicates that the patient is functioning at a better level than usual.
 26. A method for determining the appropriate medication for a patient suffering from depression, wherein when the patient's mental state is determined to be demodulation, to recommend treatment with a serotonergic antidepressant.
 27. The method of claim 26, wherein the questions concerning the patient's level of impaired modulation include at least one question about at least one of a patient's level of anxiety, irritability, hostility, impulsivity, agitation, hypochondriasis, and suicidality.
 28. The method of claim 26, wherein the serotonergic antidepressant is selected from the group consisting of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline.
 29. A method for determining the appropriate medication for a patient suffering from depression, wherein when the patient's mental state is determined to be deactivated, to recommend treatment with a catecholaminergic antidepressant.
 30. The method of claim 29, wherein the questions concerning the patient's impaired activation include at least one question about at least one of a patient's level of fatigue, apathy, anhedonia, hypersomnia, lack of initiative, inability to concentrate, and decreased productivity.
 31. The method of claim 29, wherein the at least one catecholaminergic antidepressant medication is selected from the group consisting of bupropion and bupropion SR.
 32. A method for determining the appropriate medication for a patient suffering from depression, wherein when the patient's mental state is determined to be both demodulated and deactivated, to recommend treatment with a serotonergic and catecholaminergic antidepressant or dual-mechanism antidepressant.
 33. The method of claim 32, wherein the at least one dual mechanism antidepressant medication is selected from the group consisting of venlafaxine and mirtazapine.
 34. A test for determining the appropriate medication for a patient suffering from depression, wherein when the patient's mental state is determined to be demodulated, to recommend treatment with a serotonergic antidepressant, when the patient's mental state is determined to be deactivated, to recommend treatment with a catecholaminergic antidepressant, and when the patient's mental state is determined to be both demodulated and deactivated, to recommend treatment with both a serotonergic and a catecholaminergic antidepressant or with a dual action antidepressant.
 35. The test of claim 34, wherein the test comprises written questions on a paper form.
 36. The test of claim 34, wherein the test comprises written questions entered and scored electronically.
 37. A method of using a serotonergic antidepressant for a patient who has been determined to afflicted with impaired modulation, comprising the steps of: determining that the patient is suffering from impaired modulation; determining the degree of impaired modulation; and administering an appropriate dosage of the serotonergic antidepressant to treat the impaired modulation.
 38. The method of claim 37, wherein the serotonergic antidepressant is selected from the group consisting of at least one of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline.
 39. A method of using a catecholaminergic antidepressant for a patient who has been determined to afflicted with impaired activation, comprising the steps of: determining that the patient is suffering from impaired activation; determining the degree of impaired activation; and administering an appropriate dosage of the catecholaminergic antidepressant to treat the impaired activation.
 40. The method of claim 39, wherein the at least one catecholaminergic antidepressant medication is selected from the group consisting of bupropion and bupropion SR.
 41. A method of using both a serotonergic and a catecholaminergic or a dual action antidepressant for a patient who has been determined to afflicted with impaired modulation and impaired activation, comprising the steps of: determining that the patient is suffering from impaired modulation and impaired activation; determining the degree of impaired modulation and impaired activation; and administering an appropriate dosage of the serotonergic and catecholaminergic or dual action antidepressant to treat the impaired modulation and impaired activation.
 42. The method of claim 43, wherein the serotonergic antidepressant is selected from the group consisting of at least one of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, the at least one catecholaminergic antidepressant medication is selected from the group consisting of bupropion and bupropion SR, and the dual mechanism antidepressant medication is selected from the group consisting of venlafaxine and mirtazapine.
 43. A method of determining the level of depression and/or mania and the contributing dimensions of demodulation and deactivation in a patient utilizing a bivalent number scoring criteria, wherein elevated positive demodulation and/or deactivation numbers correlate to the degree of depression the patient is experiencing, and negative deactivation numbers correlate to the degree of mania.
 44. The method of claim 43, wherein the questions concerning the patient's impaired modulation include questions about the patient's level of anxiety, anger or hostility, concern for health or hypochondriasis, irritability or annoyance, impulsivity or agitation, control of emotions, hypersomnia or amount of sleep, amount eaten, suicidality, and feeling about how the medication should make the patient feel about calmness, and the questions concerning the patient's impaired activation include questions about the patient's level of fatigue or energy, apathy or motivation, sense of enjoyment, initiative, amount of sleep, amount eaten, ability to concentrate, productivity, and feeling about how the medication should make the patient feel about being energetic.
 45. The method of claim 44, wherein the questions concerning the patient's impaired modulation and activation are scored at as both very high and very low, respectively for answers that the patient feels a lot more of the question, both high and low, respectively for answers that the patient feels somewhat more of the question, average for answers that the patient feels the same as usual of the question, both low and high, respectively for answers that the patient feels somewhat less of the question, and both very low and very high, respectively for answers that the patient feels a lot less of the question.
 46. The method of claim 45, wherein for the question about the patient's feeling about how the medication should make the patient feel about being calm and energetic, a lot more calm and energetic is rated as +4 for both, somewhat more calm and energetic is rated as +2 for both, and no more calm and energetic than usual is rated as 0 for both, and for the other questions, very high scores are equal to a score of +2, high scores are given a score of +1, average scores are given a score of 0, low scores are given a score of −1, and very low scores are equal to a score of −2, and wherein a total score for all answers of 15 and more indicates severe demodulation or deactivation, a total score for all answers of between 10 to 14 indicates moderate demodulation or deactivation, a total score for all answers of between 5 to 9 indicates mild demodulation or deactivation, and a total score of 4 or less indicates no significant demodulation or deactivation.
 47. The method of claim 44, where total scores of −1 to −5 correlates with the patient functioning at a better and less pathological level than his usual self. 